Jessie Kopp's Annotated Bibliography

Leibovici, L., Soares-Weiser, K., Paul, M., Goldberg, E., Herxheimer, A., & Garner, P. (2003). Considering resistance in systematic reviews of antibiotic treatment. Journal of Antimicrobial Chemotherapy, 52, 564-571.

This article examined the inclusion of antibiotic resistance in systematic reviews and meta-analyses on antimicrobial therapy. The authors concluded that only 40% of articles included antibiotic resistance in their discussion, 9% used antibiotic resistance in their data collection. They concluded with a call for more studies to examine the occurrence of antibiotic resistance during antimicrobial therapy.

Blazquez, J., Oliver, A., & Gomez-Gomez, J. M., (2002). Mutation and evolution of antibiotic resistance: Antibiotics as promoters of antibiotic resistance? Current Drug Targets, 3, 345-349.

This article examines the role of hypermutability and antibiotic-induced hypermutation in the spread of antibiotics as opposed to the traditional natural selection theory. The authors concluded that antibiotics can increase the rate of hypermutability. The authors suggested that studies of new antibiotics should include testing on the antibiotics ability to produce resistance.

Bennett, P. M. (2008). Plasmid encoded antibiotic resistance: Acquisition and transfer of antibiotic resistance genes in bacteria. British Journal of Pharmacology, 153, S347- S357.

This article is a review of how bacteria become resistant and transfer their resistance to other bacteria. The author describes plasmids, transposons, integrons, and gene cassettes in great detail.

Kollef, M. H., (2006). Is antibiotic cycling the answer to preventing the emergence of bacterial resistance in the intensive care unit? Clinical Infectious Diseases, 43, S82- S88.

This article reviewed the use of antibiotic cycling as a reduction technique for antibiotic resistance. Additionally, they discussed using other methods such as shorter courses of antibiotics or using antibiotics with narrow-spectrums. The authors concluded that a combination of techniques should be used to decrease the rate of antibiotic resistance in intensive care units.

Sorberg, M., Farra, A., Ransjo, U., Gardlund, B., Rylander, M., Wallen, L., Kalin, M., & Kronvall, G. (2002). Long-term antibiotic resistance surveillance of gram-negative pathogens suggests that temporal trends can be used as a resistance warning system. Scandinavian Journal of Infectious Diseases, 34, 372-378.

This article describes a 12 year longitudinal study which examined antibiotic resistance in a number of Gram-negative bacteria in relation to antibiotic consumption. They found that Escherichia coli increased its resistance to ciprofloxacin by 11%, Pseudomonas aeruginos resistance to ciprofloxacin increased 10.5%. Both increases in antibiotic resistance were prevalent after an increase in the antibiotic. However, other drugs showed a decrease in use which resulted in an increase in antibiotic resistance such as the trend they found in E. coil’s resistance to trimethoprim-sulfamethoxazole.

Canton, R. (2008). Antibiotic resistance genes from the environment: A perspective through newly identified antibiotic resistance mechanisms in clinical setting. European Society of Clinical Microbiology and Infectious Diseases, 15, 20-25.

In this article the authors consider soil bacteria’s role in antibiotic resistance. They find that bacteria from the soil may have the genetic capability to contribute to antibiotic resistance. In response they call for the use of metagenomic tools and phylogenetic analysis to identify these antibiotic resistant bacteria.

Cole, E.C., Addison, R.M., Rubino, J.R., Leese, K.E. Dulaney, M.S., Wilkins, J., Gaber, D.J., Wineinger, T., & Criger, D.A. (2003). Investigation of antibiotic and antibacterial agent cross-resistance in target bacteria from homes of antibacterial product users and nonusers. Journal of Applied Microbiology, 95, 665-676.

This study compared the occurrence of antibiotic resistance and antibiotic susceptibility in homes that either used antibacterial agents such as cleaning or hygiene products. Results indicated that homes of individuals who did not use antibacterial products had a greater amount of bacteria present. Additionally, there were no significant differences found between households of users and nonusers in regards to antibiotic resistance or susceptibility.

Normark, B. H., & Normark, S. (2002). Evolution and spread of antibiotic resistance. Journal of Internal Medicine, 252, 91-106.

This article is a review of antibiotic resistance. The authors discuss the evolution of antibiotic resistance. Additionally, they discuss how antibiotic resistance is spread including self-replicating plasmids, prophages, transposons, integrons, and resistance islands. This article is a general overview of these phenomena.

Goossens, H., Ferech, M., Stichele, R.V., Elseviers, M. (2005). Outpatient antibiotic use in Europe and association with resistance: A cross-national database study. Lancet, 365, 579-587.

This article reported the findings of a study compiling antibiotic distribution data from 26 European countries. The authors found that the countries that prescribed a greater amount of antibiotics showed increased rates of antibiotic resistance.

Wang, Y. C., & Lipsitch, M. (2006). Upgrading antibiotic use within a class: Tradeoff between resistance and treatment success. PNAS, 25, 9655-9660.

This article examined the practice of using an antibiotic in the same class when a bacterial infection has already acquired resistance to the initial antibiotic. The authors found that using an antibiotic in the same class results in greater resistance and lower failure. On the other hand, not changing to the new drug increases the risk of failure of the drug, but minimized the instance of resistance.